Publications from independent laboratory


Turan, F.B., Ercan, M.E.. Firat-Karalar, E.N (2024) A chemically inducible organelle rerouting assay to probe primary cilium assembly, maintenance and disassembly in cultured cells. Methods Mol Biol.

Alhaija, A.A., Lone, I.N., Sekeroglu, E.O., Batur, T., Angelov, D., Dimitrov, S., Hamiche, A. Firat-Karalar, E.N, Ercan, M.E., Yagci, T., Alotaibi, H., Diril, M.K.(2024) Development of a mouse embryonic stem cell model for investigating the functions of the linker histone H1-4.. FEBS Open Bio.


Deretic, J., Odabasi, E.,  Firat-Karalar, E.N (2023) The multifaceted roles of microtubule-associated proteins in primary cilium and ciliopathies. Journal of Cell Science

Odabasi, E.*, Conkar, D.*, Deretic, J., Batman, U.,  Firat-Karalar, E.N (2023) CCDC66 regulates primary cilium length and signaling via interactions with transition zone and axonemal proteins. Journal of Cell Science 

*equal contribution

Arslanhan, M.D., Cengiz-Emek, S., Odabasi, E., Steib, E., Hamel, V., Guichard, P.,  Firat-Karalar, E.N (2023) CCDC15 localizes to the centriole inner scaffold and controls centriole length and integrity. Journal of Cell Biology

Aydin, M., Uysalli, Y., Ozgonul, E., Morova, B. , Tiryaki, F. Firat-Karalar, E.N., Dogan, B, Kiraz, A(2023) An LED-based structured illumination microscope using a digitral micromirror device and GPU accelerated image reconstruction. PLOS One


Batman, U., Deretic, J.  Firat-Karalar, E.N (2022) The ciliopathy protein CCDC66 controls mitotic progression and cytokinesis by promoting microtubule nucleation and organization. PLOS Biology in press


Tiryaki, F., Deretic, J.  Firat-Karalar, E.N (2022) ENKD1 is a centrosomal and ciliary microtubule-associated protein important for primary cilium content regulation. FEBS Journal


Arslanhan, M.D., Rauniyar, N. , Yates, J.R., Firat-Karalar, E.N (2020) Aurora Kinase A proximity interactome reveals centriolar satellites as regulators of its function during primary cilium biogenesis. EMBO Reports

Biorxiv link:

Firat-Karalar, E.N (2022) A Tour de Force of Primary Cilium Biogenesis. Nature Reviews Molecular Cell Biology


Conkar, D., Firat-Karalar, E.N (2020) Microtubule-associated proteins and emerging links to primary cilium structure assembly, maintenance and disassembly. FEBS Journal 15423


Odabasi, E., Batman, U., Firat-Karalar, E.N Unraveling the mysteries of centriolar satellites: time to rewrite the textbooks about the centrosome/cilium complex (2020) Mol Biol Cell Apr 15;31(9):866-872


Aydin, O.Z., Taflan, S.O. , Gurkaslar, C.,  Firat-Karalar, E.N  Acute inhibition of centriolar satellite function and positioning reveals their functions at the primary cilium (2020) PLOS Biology


Zirhlioglu, H., Culfa, E., Arslanhan, M.D., Firat-Karalar, E.N. CCDC57 Cooperates with Microtubules and Microcephaly Protein Cep63 and Regulates Centriole Duplication and Mitotic Progression (2020) Cell Reports 


Arslanhan, M.D., Gulensoy, D., Firat-Karalar, E.N (2020) A proximity mapping journey into the biology of the mammalian centrosome/cilium complex. Cells. Jun 3;9(6):E1390.


Firat-Karalar, E.N. (2020), Proximity mapping of the microtubule plus-end tracking protein SLAIN2 using the BioID approach. Turk J Biol. Apr2;44(2):61-72


Sadeghi, S., Melikov, R. Conkar, D., Firat-Karalar, E.N., Nizamoglu, S. (2020). Ultra-Efficient and High-Quality white light-emitting devices using fluorescent proteins in aqueous medium. Advanced Materials Technologies. May 4, 2000061


Muratcioglu, S., Aydin, C., Odabasi, E., Ozdemir, S., Firat-Karalar, E.N., Jang, H., Tsai, C.J., Nussinov, R., Kavakli, I.H., Gursoy, A., Keskin, O (2020). Oncogenic KRas4B dimerization influences Erk and Akt phosphorylation. Journal of Molecular Biology, Feb 14;432(4):1199-1215


Conkar, D., Bayraktar, H., Firat-Karalar, E.N (2019) Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors. Scientific Reports. Oct 3:9(1):14250


Odabasi, E., Gul,S., Kavakli, IH., Firat-Karalar, E.N Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation (2019). EMBO Reports. Jun;20(6). pii: e47723

*published in biorxiv (


Sadeghi, S., Melikov, R. Jalali, HB., Karatum, O., Srivastava, SB., Conkar, D., Firat-Karalar, E.N., Nizamoglu, S. . Ecofriendly and efficient luminescent solar concentrators based on fluorescent proteins (2019).  ACS Applied Materials and Interfaces, 11,9, 8710-8716


Firat-Karalar, E.N. (2019) Cell Scientist to Watch. Journal of Cell Science. 132:jcs238774


Firat-Karalar, E.N., The ciliopathy gene product CEP290 is required for primary cilium formation and microtubule network organization (2018). Turkish Journal of Biology. Volume 42, Issue 5, 371 – 381


Dogru, IB., Min, K., Umar, M., Bahmanin, BJ., Begar, E., Conkar, D., Firat-Karalar, E.N., Kim, S., Nizamoglu, S. (2017). Single transverse mode protein laser. Applied Physics Letters.111 (23), 231103


Dogru, IB., Soz, CD., Press, DA, Melikov, R., Begar, E., Conkar, D., Firat-Karalar, E.N., Yilgor, E., Yilgor, I., Nizamoglu, S. (2017). 3D Coffee Stain. Materials Chemistry Frontiers. August


Conkar, D., Culfa, E., Odabasi, E., Rauniyar, N., Yates, JR 3rd, Firat-Karalar, E.N. The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking (2017). J Cell Sci. Feb 24. jcs.196832.

* Paper selected as cover article, Research Highlight in the FEBS Journal


Press, DA., Rusztamzhon, M., Conkar, D. Firat-Karalar, E.N., Nizamoglu, S. Protein Integrated Solid State Lighting (2016). Nanotechnology Volume 27, Number 45


Publications from graduate and postdoc work

Firat-Karalar, E.N., Sante, J., Elliott, S, Stearns, T. (2014). Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. J Cell Sci. Jul 29. pii: jcs.157008.


Firat-Karalar, E.N., Rauniyar, N., Yates, JR 3rd, Stearns, T. (2014). Proximity interactions among centrosome components identify regulators of centriole duplication. Curr Biol. 24(6): 664-670
* Recommended by Faculty of 1000,


Firat-Karalar, E.N. and Stearns, T. (2014). The Centriole Duplication Cycle. Philos Trans R Soc Lond B Biol Sci. Sep 5; 369(1650). pii:: 20130460.


Firat-Karalar, E.N., Hsiue, P.P., Welch, M.D (2011). The actin nucleation factor JMY is a negative regulator of neuritogenesis. Mol Biol Cell. 22(23): 4563-4574


Firat-Karalar, E.N. and M.D. Welch (2011). New mechanisms and functions of actin nucleation. Curr Opin Cell Biol. 23(1): 4-13


Goley E.D., Rammohan A, Znameroski E.A., Firat-Karalar E.N., Sept D, Welch M.D (2010). An actin-filament-binding interface on the Arp2/3 complex is critical for nucleation and branching stability. Proc Natl Acad Sci. 107(18): 8159-8164

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