Thermodynamics and an Introduction to thermostatistics
Classical thermodynamics: enthalpy, entropy, free energies, equilibria, the Legendre transform, stability of thermodynamic systems, phase transitions and critical phenomena; Introduction to statistical thermodynamics, microcanonical, canonical and grand canonical formalisms; Entropy and disorder, Fluctuations.
Textbook: Thermodynamics and an Introduction to Thermostatistics, Second Edition Herbert B. Callen, Wiley, 1985
The course consists of two parts. In the first part, a web based review of drug design will be made. Some of the subjects to be covered are: Effects of nonsteroidal anti inflammatory drugs. Case study: Aspirin. The Renin-Angiotensin System and drugs used for diseases of this system. Drug binding thermodynamics. Enzyme inhibition. Dopamine transporters. Ion channels and drugs used in blocking the channels. Gaba receptor and pain. Peptides as drugs. In the second part, each student will design a drug for a given pathway or disease, using the tools of drug design that we will learn in class.
Textbook: The Organic Chemistry of Drug Design and Drug Action by Richard Silverman Elsevier 2004