Peer Reviewed Publications

Researchgategoogle scholar

55. Nihal O Dogan, Ugur Bozuyuk, Pelin Erkoc, Alp C Karacakol, A Cingoz, F Seker-Polat, M Anwaar Nazeer, Metin Sitti*, Tugba Bagci-Onder*, Seda Kizilel* “Parameters Influencing Gene Delivery Efficiency of PEGylated Chitosan Nanoparticles: Experimental and Modeling Approach“,  Advanced NanoBiomed Research, 2021.

54. S. Rubab Batool, M. Anwaar Nazeer, Erdost Yildiz, Afsun Şahin,  Seda Kizilel* Chitosan-Anthracene Hydrogels as Controlled Stiffening NetworksInternational Journal of Biological Macromolecules, 2021.

53. M. Anwaar Nazeer, İsmail C Karaoglu, Onur Ozer, Cem Albayrak*,  Seda Kizilel* Neovascularization of engineered tissues for clinical translation: where we are, where we should be?APL Bioengineering (This paper has been selected as Editor’s Pick), Feb 2021.

52.  M Birgül Akolpoğlu+, Yasemin İnceoğlu+, Ugur Bozuyuk, Ana Rita Sousa, Mariana B. Oliveira‡*, João F. Mano, Seda Kizilel†,*  “Recent Advances in the Design of Implantable Insulin Secreting Heterocellular Islet OrganoidsBiomaterials (Impact Factor: 10.317), Oct 2020.            (+: equal authorship)

51. Pelin Erkoc*, Ileyna Uvak, M Anwaar Nazeer, S Rubab Batool, Ozan Akdogan*, Seda Kizilel*3D Printing of Cytocompatible Gelatin-Cellulose-Alginate Blend Hydrogels” accepted, Macromolecular Bioscience, July 2020.

50. M Birgül Akolpoğlu+, Nihal O Dogan+, Ugur Bozuyuk+, Hakan Ceylan*, Seda Kizilel*, Metin Sitti* High-Yield Production of Biohybrid Microalgae for On-Demand Cargo DeliveryAdvanced Science (Impact Factor: 15.804), May 2020.

49. Syeda Rubab Batool, Muhammad Anwaar Nazeer, Duygu Ekinci, Afsun Sahin, Seda Kizilel* “Multifunctional Alginate-based Hydrogel with Reversible Crosslinking for Controlled Therapeutics DeliveryInternational Journal of Biological Macromolecules, Feb 2020.

48. M Birgül Akolpoğlu, Yasemin İnceoğlu, Seda Kizilel*An All-Aqueous Approach for Physical Immobilization of PEG-lipid Microgels on Organoid Surfaces“, in press, Colloids and Surfaces B: Biointerfaces, 5 December 2019, 110708, 2019.

47. T Bal, Y Inceoglu, E Karaoz, Seda Kizilel*Sensitivity study for the key parameters in Heterospheroid Preparation with Insulin-Secreting β-Cells and Mesenchymal Stem CellsACS Biomaterials Science & Engineering, 10.1021/acsbiomaterials.9b00570, August 2019.

46. Dilem C Oran, M.B. Akolpoglu, Y. Inceoglu, T Lokumcu, O Albayrak, T Bal, M Kurtoğlu, M Erkan, F Can, T Bagci-Onder, Seda Kizilel* “Engineering Human Stellate Cells for Beta Cell Replacement Therapy Promotes in vivo Recruitment of Regulatory T cells (Tregs)Materials Today Bio, accepted, May 2019.

45. Betul Bingol, Sesil Agopcan-Cinar, Tugba Bal, D. Ceren Oran, Seda Kizilel, Nilhan Kayaman-Apohan, Duygu Avci* “Stimuli‐responsive Poly(hydroxyethyl methacrylate) Hydrogels from Carboxylic Acid‐Functionalized CrosslinkersJournal of Biomedical Materials Research Part A, May 2019.

44. Ugur Bozuyuk, Ipek Gokulu, Nihal O Dogan, Seda Kizilel* “A Novel Method for PEGylation of Chitosan Nanoparticles through Photopolymerization RSC Advances, 10.1039/C9RA00780F, 2019.

43. C. Kekec, M. B. Akolpoglu, U. Bozuyuk, S. Kizilel, N.Nugay*, T. Nugay, J.P. Kennedy* “Calcification resistance of polyisobutylene and polyisobutylene-based materials”, Polymers for Advanced Technologies, DOI: 10.1002/pat.4616, March 2019.

42. Pelin Erkoc, Nihal O. Dogan, Seda Kizilel* “Optimization of Gelatin-Potassium Phosphate Aqueous Two-phase System for the Preparation of Hydrogel MicrospheresJournal of the Minerals, Metals, and Materials Society (JOMJ),, 2019.

Will appear in the Special Issue on “Protein-Based Structural Materials”

41. Ugur Bozuyuk, Nihal Olcay Dogan, Seda Kizilel* “Deep insight into PEGylation of bioadhesive chitosan nanoparticles: Sensitivity analysis for the key parameters through artificial neural network model” ACS Applied Materials & Interfaces, DOI: 10.1021/acsami.8b11178, Sep 2018.

40. Ugur Bozuyuk, Oncay Yasa, I Ceren Yasa, Hakan Ceylan*, Seda Kizilel*, Metin Sitti*Light-Triggered Drug Release from 3D-Printed Magnetic Chitosan Microswimmers” ACS Nano, 10.1021/acsnano.8b05997, August2018.

39. M.N. Guven+ , M.S. Altuncu+, T. Bal , D.C. Oran, U. Gulyuz, S Kizilel, O. Okay, D. Avci* “Bisphosphonic acid functionalized crosslinkers to tailor hydrogel properties for biomedical applications” DOI1021/acsomega.8b01103 ACS Omega, 2018.

38. Derya Aydin, M. Birgul Akolpoglu, Riza Kizilel, Seda Kizilel* “Anti-Icing Properties on Surfaces through Functional Composite: Effect of Ionic SaltsDOI: 10.1021/acsomega.8b00816 ACS Omega, 2018.

37. Tugba Bal, Dilem C Oran, Yoshihiro Sasaki, Kazunari Akiyoshi, Seda Kizilel* “Sequential Coating of Insulin Secreting Beta Cells within Multilayers of Polysaccharide NanogelsMacromolecular BioscienceDOI: 10.1002/mabi.201800001, 25 March 2018.

36. Derya Aydin, Seda Kizilel* “P2X7 Receptor Antagonist Delivery Vehicle Based on Photocrosslinked Amphiphilic Hybrid GelsRSC Advances,DOI: 10.1039/c8ra01460d2018.

35. Pelin Erkoc, Fidan Seker, Tugba Bagci-Onder*, Seda Kizilel* “Gelatin Methacryloyl Hydrogels in the Absence of a Crosslinker as 3D Glioblastoma Multiforme (GBM)-Mimetic MicroenvironmentMacromolecularBioscienceDOI: 10.1002/mabi.2017003692018.

34. Sadi Gurses, Can Erkey, Seda Kizilel*, Alper Uzun* “Characterization of Sodium Tripolyphosphate and Sodium Citrate Dehydrate Residues on Surfaces” Talanta, Vol 176, pp 8-16 August 2017.

33. Gunce E Cinay, Pelin Erkoc, Mohammad Alipour, Yoshihide Hashimoto, Yoshihiro Sasaki, Kazunari Akiyoshi, Seda Kizilel* “Nanogel-integrated pH Responsive Composite Hydrogels for Controlled Drug Delivery” ACS Biomaterials Science & Engineering DOI: 10.1021/acsbiomaterials.6b00670, Jan 2017.

32. Pelin Erkoc, Ahmet Cingoz, Tugba Bagci-Onder*, Seda Kizilel* “Quinacrine Mediated Sensitization of Glioblastoma (GBM) cells to TRAIL through MMP-sensitive PEG Hydrogel Carriers” Macromolecular Bioscience, DOI: 10.1002/mabi.201600267, Vol 17, Issue 2, 20 October 2016.

FEATURED as Frontispiece in  this issue of Macromolecular Bioscience.

31. Aysu C Okur+, Pelin Erkoc+, Seda Kizilel* “Targeting Cancer Cells via Tumor-homing Peptide CREKA Functional PEG Hydrogel Nanoparticles” Colloids and Surfaces B: Biointerfaces, 10.1016/j.colsurfb.2016.08.005, August 2016.

30. Derya Aydin, Seda Kizilel* “Water-in-Water Emulsion Based Synthesis of Hydrogel Nanospheres with Tunable Release Kinetics” Journal of the Minerals, Metals, and Materials Society (JOMJ), DOI: 10.1007/s11837-016-1969-z, 2016.

 INVITED – Special Issue on “Biomaterials for Healthcare”

29. Derya Aydin, Riza Kizilel, Ramazan O Caniaz, Seda Kizilel* “Gelation Stabilized Functional Composite-Modified Bitumen for Anti-icing Purposes” DOI: 10.1021/acs.iecr.5b03028, Industrial and Engineering Chemistry Research, Nov 2015.

This article in I&ECR has been selected as the topic of a press release that is included in the American Chemical Society (ACS) Office of Public Affairs’ weekly presspac.

Here are some of the news about our work:  SciencedailyScience Newsline, NTVTGRTHALKTVKANAL 24

28. Dogan Gidon+, Derya Aydin+, Seda Kizilel* “Photocrosslinking of Styrene-Butadiene-Styrene (SBS) Networks formed by Thiol-Ene Reactions and Their Influence on Cell Survival” doi:10.1088/1748-6041/10/6/065001, Biomedical Materials, October 2015 (+:equal authorship).

27. Gozde S Demirer, Aysu C Okur, Seda Kizilel* “Biologically Inspired Design of Biocompatible Iron Oxide Nanoparticles for Biomedical Applications” Journal of Materials Chemistry B, DOI: 10.1039/c5tb00931f, July 2015.

INVITED – Special Issue on “Bioinspired and Natural Materials” 

26.  H. Betul Bingol, Ayse Altin, Tugba Bal, Sesil Agopcan-Cinar, Seda Kizilel, Duygu Avci* “Synthesis and evaluation of new phosphonic acid-functionalized acrylamides with potential biomedical applicationsJournal of Polymer Science Part A,  DOI: 10.1002/pola.27746, 2015.

25. Ozlem Cevik, Dogan Gidon, Seda Kizilel* “Visible-Light-Induced Synthesis of pH Responsive Hydrogel Composite for Controlled Delivery of an Anticonvulsant Drug Pregabalin” in press, Acta Biomaterialia,10.1016/j.actbio.2014.09.018, January 2015.

24.Tugba Bal, Caner Nazli, Alparslan Okcu, Gokhan Duruksu, Erdal Karaoz, Seda Kizilel* “Mesenchymal Stem Cells (MSCs) and Ligand Incorporation in Biomimetic PEG Hydrogels Significantly Improve Insulin Secretion from Pancreatic Islets” Journal of Tissue Engineering and Regenerative Medicine, DOI:10.1002/term.1965, 2014.

23. Caner Nazli, Gozde S Demirer, Y Yar, H. Yagci Acar, Seda Kizilel* “Targeted Delivery of Doxorubicin into Tumor Cells via MMP-sensitive PEG Hydrogel Coated Magnetic Iron Oxide Nanoparticles (MIONPs)“, Colloids and Surfaces B: Biointerfaces, 10.1016/j.colsurfb.2014.07.049, 2014.

22. Burcu Kepsutlu, Caner Nazli, Tugba Bal, Seda Kizilel* “Design of Bioartificial Pancreas with Functional Micro/Nano Based Encapsulation of Islets” Current Pharmaceutical Biotechnology, 15(7), 590-608, 2014. DOI: 10.2174/1389201015666140915145709

INVITED – Special Thematic Issue on “Nanotechnology as a Strategy to Improve Treatment of Diabetes”

21.K Golab, S Kizilel, T Bal, M Hara, M Zielinski, R Grose, O Savari, XJ Wang, J Grzanka, L-J Wang, M Tibudan, A Krzystyniak, N Marek-Trzonkowska, JM Millis, P Trzonkowski, P Witkowski “Improved Coating of Pancreatic Islets with Regulatory T cells (Tregs) to Create Local Immunosuppression by Using Biotin-Polyethylene glycol-Succinimidyl Valeric Acid Ester Molecule.” Transplantation Proceedings Volume 46, Issue 6, July-August 2014, Pages 1967-1971, DOI: 10.1016/j.transproceed.2014.05.075.

20. Burcu Kepsutlu, Riza Kizilel, Seda Kizilel* “Quantification of Interactions Among Circadian Clock Proteins via SPR” Journal of Molecular Recognition, DOI: 10.1002/jmr.2367,  2014.

19. Selin Kanyas, Derya Aydin, Riza Kizilel, A. Levent Demirel, Seda Kizilel*, “Nanoparticle and Gelation Stabilized Functional Composites of an Ionic Salt in a Hydrophobic Polymer Matrix”  PLoS ONE, DOI: 10.1371/journal.pone.0088125, 2014.

18. Tugba Bal, Burcu Kepsutlu, Seda Kizilel*, “Characterization of Protein Release through PEG Hydrogels with Crosslink Density Gradients” DOI: 10.1002/jbm.a.34701, Journal of Biomedical Materials Research Part A, March 2013.

17. Selimcan Azizoglu, Riza Kizilel, Maja Marusic, I. Halil Kavakli, Burak Erman, Seda Kizilel,* “Computational and Experimental Investigation of Drug-Protein Interactions” Journal of Molecular Recognition, DOI: 10.1002/jmr.2258, 26: 297-307, 2013.

16. Riza Kizilel,* Enis Demir, Selimcan Azizoglu, Hande Asimgil, I. Halil Kavakli,* Seda Kizilel,* “Investigation of Real-Time Photorepair Activity on DNA via Surface Plasmon Resonance (SPR)” PLoS ONE, 7(8): e44392. doi:10.1371/journal.pone.0044392, 2012.

15. Caner Nazli, T. Ipek Ergenc, Yasemin Yar, Funda Yagci Acar, Seda Kizilel* “RGDS Functionalized Poly(ethylene glycol) (PEG) Hydrogel Coated Magnetic Iron Oxide Nanoparticles Enhance Specific Intracellular Uptake by HeLa Cells” International Journal of Nanomedicine, 7:1903-1920, 2012.

14. Bilal Cakir, Onur Dagliyan, Ezgi Dagyildiz, Ibrahim Baris, I. Halil Kavakli*, Seda Kizilel*, Metin Turkay* “Structure Based Discovery of Small Molecules to Regulate the Activity of Insulin Degrading Enzyme” PLoS ONE, 7(2): e31787, DOI: 10.1371/journal.pone.0031787, 2012.

13. Riza Kizilel, Seda Kizilel* “Application of Numerical Fractionation Approach for the Design of Biofunctional PEG Hydrogel Membrane” Macromolecular Reaction Engineering, March 13, DOI:10.1002/mren.201100073, 2012 (APPEARED AS COVER).(pdf)

12. Seda Giray, Tugba Bal, Ayse Meric Kartal, Seda Kizilel,* and Can Erkey* “Controlled Drug Delivery through a Novel PEG Hydrogel Encapsulated Silica Aerogel System” Journal of Biomedical Materials Research Part A, DOI: 10.1002/jbm.a.34056, 2012.

11. Natalia Marek+, Adam Krzystyniak+, T. Ipek Ergenc+, Olivia Cochet, Ryosuke Misawa, Ling-Jia Wang, Seda Kizilel, Piotr Trzonkowski, Michael Millis, Piotr Witkowski “Coating of Human Pancreatic Islets with CD4+CD25highCD127-T Regulatory Cells-a Novel Immunosuppressive Approach” Annals of Surgery, Volume 254, Number 3, September 2011 (+ = equal authorship). (pdf)

10. Seda Keskin and Seda Kizilel “Biomedical Applications of Metal Organic Frameworks” Industrial and Engineering Chemistry Research, 50(4), 1799-1812, 2011.

9. Seda Kizilel* “Mathematical Model for Microencapsulation of Pancreatic Islets within Biofunctional PEG Hydrogel” , Macromolecular Theory and Simulations, 2010, 19(8-9):514-531. (pdf)

8. Seda Kizilel*, Andrew Scavone, Xiang Liu, Jean Manuel Nothias, Diane Ostrega, Piotr Witkowski, J Michael Millis “Encapsulation of Pancreatic Islets Within Nano-Thin Functional Polyethylene Glycol Coatings for Enhanced Insulin Secretion.” Tissue Engineering Part A, 2010, 16(7):2217-28. (pdf)

7. Seda Kizilel*, Fouad Teymour, and Victor H. Perez-Luna “Modeling of PEG Hydrogel Membrane for Biomedical Applications“, Macromolecular Reaction Engineering, 2009, 3:271-287.(pdf)

6. Seda Kizilel, Georgia Papavasiliou, John Gossage, Fouad Teymour* “Mathematical Model for Vinyl-Divinyl Polymerization” Macromolecular Reaction Engineering, 2007, 1: 587-603.(pdf)

5. J.L. Wyman, S. Kizilel, R. Skarbek, X. Zhao, M. Connors, W.S. Dillmore, W.L. Murphy, M. Mrksich, S.R. Nagel, M.R. Garfinkel. Immunoisolating pancreatic islets by encapsulation with selective withdrawal. Small, 2007, 3:683-690.

4. Seda Kizilel, Erin Sawardecker, Victor H. Perez-Luna*, and Fouad Teymour, “Sequential Formation of Covalently Bonded Hydrogel Multilayers through Surface Initiated Photopolymerization” Biomaterials, 2006; 27(8):1209-1215.(pdf)

3. Seda Kizilel*, Fouad Teymour, and Victor H. Perez-Luna “Mathematical Model for Surface Initiated Photopolymerization of Poly(ethylene glycol) Diacrylate” Macromolecular Theory and Simulations, 2006; 15(9):686-700.(pdf)

2. Seda Kizilel, Marc Garfinkel, Emmanuel Opara* “The Bioartificial Pancreas: Progress and Challenges” Diabetes Technology and Therapeutics, 2005; 7(6):968-985.(pdf)

1. Seda Kizilel, Victor H. Perez-Luna*, and Fouad Teymour “Photopolymerization of poly(ethylene glycol) diacrylate on eosin-functionalized surfaces” Langmuir , 2004; 20(20); 8652-8658.(pdf)